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Preclinical Animal Models & CRO Services
Services: In-House Models | Will Travel Services
Animal Models:
Biotrofix offers special expertise in rodent models of neurological and vascular diseases, including:
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PK/PD Studies - mouse and rat studies of drug pharmacokinetics and pharmacodynamics |
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Acute Stroke - mouse and rat models of acute focal cerebral ischemia, suitable for testing of neuroprotective treatments |
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Stroke Recovery - rat models of focal cerebral ischemia compatible with prolonged animal survival, suitable for testing of recovery-promoting treatments |
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Alzheimer's Disease (AD) - transgenic mouse models of amyloid deposition and neuronal loss, suitable for testing of AD treatments |
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Amyotrophic Lateral Sclerosis (ALS) - transgenic mouse models of mutant SOD-1 expression, suitable for testing of ALS treatments |
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Traumatic Brain Injury (TBI) - rat models of TBI, suitable for testing of neuroprotective or recovery-promoting strategies |
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Spinal Cord Injury (SCI) - mouse and rat models of SCI, suitable for testing of neuroprotective or recovery-promoting strategies |
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Muscular Dystrophy (MD) - transgenic mouse models of muscular dystrophy, suitable for testing of appropriate treatments |
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Myocardial Infarction (MI) - mouse and rat models of acute MI, suitable for testing of cardioprotective treatments |
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Peripheral Vascular Disease (PVD) - mouse and rat models of PVD, suitable for testing of appropriate treatments |
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Other Diseases - mouse and rat models of muscular dystrophy, diabetes, peripheral vascular disease, and others under development |
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Will Travel Services - Biotrofix personnel will travel to other companies |
Drug Administration:
Delivery of small molecules, proteins, cells, or appropriate devices in the models above via intracerebral, intrathecal, systemic, oral, or local administration, either by injection or continuous infusion. Single, multiple, or continuous dosing.
Behavioral Assessment:
Biotrofix investigators are highly-experienced in behavioral assessment in rodent models of neurological and vascular diseases. These include assessment of:
- Sensorimotor Function: limb placing tests, tail swing test, neurological severity scale, beam balance, spontaneous limb use, grid walking, staircase, sticky tape, paw reaching, rotorod, and rotating beam tests.
- Memory: novel object recognition, Morris water maze test, contextual fear conditioning.
- Other model-specific behavioral tests are also available.
Tissue Sampling and Histology:
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Blood, urine, and CSF sampling for PK and PD studies. |
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Brain and other organ harvesting, fixation, sectioning, and routine histological processing. |
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Infarct volume analysis for stroke studies. |
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Immunocytochemistry studies are done through special arrangement. |
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Preclinical Research - Drug Discovery & Development
Biotrofix provides preclinical contract research services, Preclinical Research, Preclinical Drug Discovery & Preclinical Drug Development for clients in the pharmaceutical and biotechnology industries, and represents the cutting edge of preclinical research today.
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